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    • Hematology - Myelodysplastic Syndrome International Prognostic Scoring System

    Myelodysplastic Syndrome International Prognostic Scoring System

    Select Criteria:
    Percentage of Bone Marrow Blasts
    < 5 percent (0 points)
    5 to 10 percent (0.5 points)
    11 to 20 percent (1.5 points)
    21 to 30 percent (2.0 points)
    Karyotype
    Normal, Y-, 5q-, 20q- (0 points)
    Abnormal chromosome 7 or 3 or more abnormalities (1.0 points)
    All other cytogenic abnormalities (0.5 points)
    Cytopenias (defined as hemoglobin < 10 g/dL, absolute neutrophil count < 1800/microL, platelet count < 100,000/microL)
    No cytopenia or cytopenia of 1 cell type (0 points)
    Cytopenia of 2 or 3 cell types (0.5 points)
    Results: Total Criteria Point Count:
    Prognostic Score Interpretation
    0 Points:Low (Median Survival of 5.7 yrs)
    0.5 - 1 Points:Intermediate 1 (Median Survival of 3.5 yrs.)
    1.5 - 2.0 Points:Intermediate 2 (Median Survival of 1.2 yrs.)
    2.5-3.5 Points:High (Median Survival of 0.4 yrs.)
    1. Greenberg P, Cox C, LeBeau MM et. al. International Scoring System for Evaluating Prognosis in Myelodysplastic Syndromes. Blood. 1997; 89;6: 2079 - 2088. Erratum in Blood 1998; 91:1100.
    2. Heaney ML, Golde, DW. Medical Progress: Myelodysplasia. NEJM. 1999; 340;21: 1649-1660.
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