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    • Heart and Chest - Endocarditis Diagnostic Criteria (Duke Criteria)

    Endocarditis Diagnostic Criteria -- Duke Criteria

    Select Criteria:

    		Diagnostic : 2 Major Criteria and 0 Minor Criteria

    		Diagnostic : 1 Major Criteria and 3 Minor Criteria

    		Diagnostic : 0 Major Criteria and 5 Minor Criteria
     
    Major Diagnostic Criteria
    Positive blood culture for typical Infective Endocarditis organisms (strep viridins or bovis, HACEK, staph aureous without other primary site, enterococcus), from 2 separate blood cultures or 2 positive cultures from samples drawn > 12 hours apart, or 3 or a majority of 4 separate cultures of blood (first and last sample drawn 1 hour apart)
    Echocardiogram with oscillating intracardiac mass on valve or supporting structures, in the path of regurgitant jets, or on implanted material in the absence of an alternative anatomic explanation, or abscess, or new partial dehiscence of prosthetic valve or new valvular regurgitation
    Minor Diagnostic Criteria
    Predisposing heart condition or intravenous drug use
    Temp > 38.0° C (100.4° F)
    Vascular phenomena: arterial emboli, pulmonary infarcts, mycotic aneurysms, intracranial bleed, conjunctival hemorrhages, Janeway lesions
    Immunologic phenomena: glomerulonephritis, Osler nodes, Roth spots, rheumatoid factor
    Microbiological evidence: positive blood culture but does not meet a major criterion as noted above or serological evidence of active infection with organism consistent with endocarditis (excluding coag neg staph, and other common contaminants)
    Echocardiographic findings: consistent with endocarditis but do not meet a major criterion as noted above
    Results:
    1. Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service. American Journal of Medicine. 96(3):200-9, 1994.
    2. Lukes AS, Bright DK, Durack DT. Diagnosis of infective endocarditis. Infect Dis Clin North Am. 1993 Mar;7(1):1-8. Review.
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