When This Medicine Should Not Be Used:
Do not use this medicine if you have had an allergic reaction to lubiprostone, or if you have a history of a stomach or bowel blockage.

How to Use This Medicine:
Capsule, Liquid Filled Capsule

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• Take this medicine with food and water. This will help lessen the chance of nausea.
• Swallow the capsule whole. Do not crush, break, or chew it.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you also use methadone (Dolophine®).

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding, or if you have liver disease, stomach pain, nausea, vomiting, severe diarrhea, or a sudden change in bowel movements.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Severe diarrhea, stomach pain or swelling
• Severe nausea or vomiting
• Trouble breathing

If you notice these less serious side effects, talk with your doctor:

• Headache
• Mild nausea
• Passing gas

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088