When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to this type of medicine before (such as Panafil® or Gladase®-C), or if you have had an allergic reaction to papain or urea.

How to Use This Medicine:
Foam, Spray, Liquid, Ointment, Gel/Jelly

• Your doctor will tell you how much medicine to use. Do not use more than directed.
• Wash your hands with soap and water before and after you use this medicine. This medicine should only be used on your skin. Do not get this medicine in your eyes, nose, or mouth.
• Before using a new spray bottle, prime the pump by holding the spray upright directly over the wound, and pumping 6 to 8 times.
• Once the spray pump has been primed, hold the bottle about 2 to 3 inches from your wound to apply. Use even, firm, and equal pressure each time you pump the bottle. Completely cover your wound site with the medicine. You should not be able to see the wound under the medicine. Then, follow your doctor's directions for dressing (covering) the wound.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Avoid using medications on your wound that contain metals such as lead, silver, and mercury. Make sure your doctor knows about all other medicine and wound treatments you are using.
• Do not use hydrogen peroxide on your wound when using this medicine, unless your doctor tells you to.

Warnings While Using This Medicine:

• Follow your doctor's instructions about how to care for your wound before and after using this medicine.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

• Burning or irritation of the wound.

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088