When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to human protein C, mouse proteins, or heparin.

How to Use This Medicine:
Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are using a blood thinner (such as warfarin, Coumadin®), alteplase (Activase®), or tenecteplase (Tnkase®).

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding, if you have kidney disease, or if you are on a low-sodium diet.
• This medicine may cause allergic reactions. Stop using this medicine and tell your doctor right away if you have itching, hives, trouble breathing, or any swelling of your hands, face, or mouth when you use this medicine.
• This medicine is made from donated human blood. Some human blood products have transmitted certain viruses to people who have received them. The risk of getting a virus from medicines made of human blood has been greatly reduced in recent years. This is the result of required testing of human donors for certain viruses, and testing during manufacture of these medicines. Although the risk is low, talk with your doctor if you have concerns.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Chest pain or shortness of breath.
• Fever.
• Lightheadedness or fainting.

If you notice these less serious side effects, talk with your doctor:

• Increased sweating.
• Itching or skin rash.
• Restlessness.

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088