When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to ticlopidine, or if you have severe liver disease, a bleeding disorder or active bleeding (such as a bleeding ulcer or a head injury), or a condition called thrombocytopenic purpura (TTP).

How to Use This Medicine:
Tablet

• Your doctor will tell you how much of this medicine to take and how often. Do not take more medicine or take it more often than your doctor tells you to.
• It is best to take this medicine with food to avoid stomach upset.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are also using antacids (Maalox®, Mylanta®), blood thinners (Coumadin®), cimetidine (Tagamet®), phenytoin (Dilantin®), propranolol (Inderal®), theophylline, or pain or arthritis medicine (such as aspirin, diclofenac, etodolac, ibuprofen, Advil®, Aleve®, Orudis®, Daypro®, Feldene®, Indocin®, Relafen®, Voltaren®).

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding, or if you have kidney disease, or have recently been injured or had surgery.
• Your doctor will need to check your blood at regular visits while you are using this medicine. It is very important that you keep all appointments for blood tests.
• This medicine can lower the number of certain types of blood cells in your body. Because of this, you may be more likely to get an infection or illness, and you may bleed more easily. To prevent these problems, avoid being near people who are sick or have infections. Wash your hands often. Avoid activities or situations in which you may get cut, bruised, or injured. Brush and floss your teeth gently. Use an electric razor instead of a razor blade when shaving.
• Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine for 10 to 14 days before having surgery.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
• Blistering, peeling, red skin rash
• Dark-colored urine or pale stools
• Fever, chills, sore throat
• Numbness, tingling, or burning pain in your hands, arms, legs, or feet
• Red pinpoint spots on the skin
• Severe diarrhea, nausea, vomiting, loss of appetite, or pain in the upper stomach
• Unusual bleeding, bruising, or weakness
• Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

• Bloating, gas, stomach pain or upset
• Dizziness
• Mild diarrhea, nausea, vomiting, loss of appetite
• Mild skin rash

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088