When This Medicine Should Not Be Used:
You should not use this medicine if you have ever had an allergic reaction to octreotide.

How to Use This Medicine:
Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin or into a vein.
• A nurse or other trained health professional will give you this medicine.
• You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection.
• You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
• Use a new needle and syringe each time you inject your medicine.
• Never share your medicine with anyone.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are also using cyclosporine (Sandimmune®), diabetes medicine (insulin or oral medicine such as Actos™, Avandia®, Glucotrol®, Glyburide®), blood pressure medicine (such as atenolol, metoprolol, propranolol, Toprol®), heart medicine (such as verapamil, Adalat®, Cardizem®, Plendil®, Procardia®), diuretics (water pills such as furosemide, Norvasc®), or potassium supplements.

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding, or if you have psoriasis, heart or thyroid problems, diabetes, hypoglycemia (low blood sugar), or severe kidney disease.
• Side effects tend to be more severe in patients who are taking octreotide for acromegaly.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in face or hands, swelling or tingling in the mouth or throat, tightness in chest, trouble breathing
• Fast, slow, or irregular heartbeat
• Increase in how much or how often you urinate, increased thirst or hunger, weight loss
• Nervousness, shakiness, sweating, sudden hunger
• Severe pain in the upper or upper right abdomen, especially spreading to the side or back
• Severe stomach pain
• Unusual tiredness or weakness, coldness, weight gain
• Yellow skin or eyes

If you notice these less serious side effects, talk with your doctor:

• Pain, burning, or itching where the IV or shot is given
• Nausea, constipation, stomach cramps, increased diarrhea

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088