When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to lomustine, or if you are pregnant.

How to Use This Medicine:
Capsule

• Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• You may have two or more different capsules that make up your dose. If so, you can take all of the capsules at once. Ask your doctor or pharmacist about this before you take the medicine.
• Take the medicine on an empty stomach. Your doctor may tell you to take the medicine at bedtime to keep you from having nausea.
• After you take your dose, you will not take any more of the medicine for at least 6 weeks.
• Wear gloves when touching the capsules. Do not break, crush, or open the capsules. If any of this medicine gets on your skin or in your nose or mouth, wash the area with soap and water right away. If the medicine gets in your eyes, wash them with water right away and call your doctor.
• You may also receive medicines to help prevent nausea and vomiting.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• This medicine may interfere with vaccines. Ask your doctor before you get a flu shot or any other vaccines.

Warnings While Using This Medicine:

• It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
• Make sure your doctor knows if you are breastfeeding, or if you have kidney disease, liver disease, lung disease, bone marrow problems (anemia, leukopenia), chicken pox, shingles, or any type of infection.
• This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
• Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Confusion.
• Dark-colored urine or pale stools.
• Decrease in how much or how often you urinate.
• Fever, chills, cough, sore throat, and body aches.
• Nausea, vomiting, loss of appetite, or pain in your upper stomach.
• Severe diarrhea.
• Shortness of breath or trouble with breathing.
• Sores or white patches on your lips, mouth, or throat.
• Swelling of feet or lower legs.
• Unusual bleeding, bruising, or weakness.
• Yellowing of your skin or the whites of your eyes.

If you notice these less serious side effects, talk with your doctor:

• Blurred vision.
• Hair loss.
• Loss of appetite.
• Sores or white patches on your lips, mouth, or throat.

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088