When This Medicine Should Not Be Used:
You should not use this medicine if you have had an allergic reaction to nisoldipine or to similar medicines (such as verapamil, Adalat®, Calan®, Cardizem®, Lotrel®, Plendil®, Procardia®).

How to Use This Medicine:
Long Acting Tablet

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• Swallow the extended-release tablet whole. Do not crush, break, or chew it.
• It is best to take this medicine on an empty stomach.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• There are many other medicines that can interact with nisoldipine. Make sure your doctor knows about ALL other medicines you are using. This includes over-the-counter medicines that can increase your blood pressure (such as diet pills, cold and allergy medicines, or asthma medicines).
• Do not drink alcohol while you are using this medicine.
• Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding, or if you have heart disease, liver disease, stomach problems, or aortic stenosis (narrowing of a valve in your heart).
• This medicine may make you dizzy or lightheaded. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
• Do not stop using this medicine suddenly. Your doctor will need to slowly decrease your dose before you stop it completely.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Chest pain.
• Fast, irregular, or pounding heartbeats.
• Lightheadedness, dizziness, or fainting.
• Rapid weight gain.
• Shortness of breath or wheezing.
• Swelling in your hands, ankles, or feet.
• Unusual tiredness or weakness.
• Warmth or redness in your face, neck, arms, or upper chest.

If you notice these less serious side effects, talk with your doctor:

• Cough, runny or stuffy nose, or sore throat.
• Headache.
• Skin rash.
• Stomach discomfort or nausea.

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088