When This Medicine Should Not Be Used:
You should not use this medicine if you have ever had an allergic reaction to cefoperazone or any other cephalosporin medicine such as Keflex®, Ceclor®, or Duricef®.

How to Use This Medicine:
Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given.
• An IM injection is a shot given in your muscle (upper arm, thigh, buttocks). An IV infusion is medicine that is put directly into your body through one of your veins.
• This medicine should be given by a person trained to give IV or IM medicine, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
• If you are receiving IV medicine, check the bag to make sure there are no leaks. Also make sure the solution is clear.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are taking a blood thinner such as Coumadin®.
• Do not drink alcohol while taking this medicine.

Warnings While Using This Medicine:

• If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
• Before taking this medicine, let your doctor know if you have ever had an allergic reaction to penicillin.
• Make sure your doctor knows if you have liver or kidney disease or if you have ever had colitis.
• If you have severe diarrhea while taking cefoperazone, check with your doctor before taking medicine to stop the diarrhea.
• If your infection does not improve, or if it gets worse, while taking this medicine, talk to your doctor.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Rash or hives
• Swelling of the face, throat, or lips
• Wheezing or trouble breathing
• Severe diarrhea (watery or bloody)
• Severe vomiting or stomach pain
• Swelling, pain, or redness near where your IV is located
• Unusual bleeding or bruising

If you notice these less serious side effects, talk with your doctor:

• Mild diarrhea or nausea
• Vaginal itching or discharge
• Pain where the IM shot was given

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088