When This Medicine Should Not Be Used:
You should not receive this medicine if you have had an allergic reaction to methacholine or similar medicines. Make sure your doctor knows about any allergies to medicine you may have. You should not receive this medicine at the same time that you are having an asthma attack, wheezing, trouble breathing, or if you have a severe decrease in lung function. You should not receive this medicine if you are also taking a beta blocker. Beta blockers are usually used to treat heart or blood pressure problems. Examples include atenolol (Toprol®), metoprolol, or propranolol. Make sure your doctor knows about all of the medicine you are taking.

How to Use This Medicine:
Liquid Under Pressure

• A nurse or other trained health professional will give you this medicine.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Certain medicines may interfere with your test. Your doctor may need to adjust the dose of some of your medicine before your test, or you may need to stop taking certain medicines for a short time before your test. Follow your doctor's instructions.

Warnings While Using This Medicine:

• Make sure your doctor knows if you are pregnant or breastfeeding. Your test may need to be scheduled within ten days of the start of your last period, or within ten days of your last negative pregnancy test.
• Make sure your doctor knows if you have epilepsy, heart disease or heart rhythm problems, circulation problems, or a history of nerve problems or fainting. Tell your doctor if you have a history of ulcers, thyroid problems, constipation, or a blocked urinary tract. Make sure your doctor knows if you are taking medicine to treat myasthenia gravis. Tell your doctor about any other medical problems you may have, or that you have had in the past.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Lightheadedness.
• Wheezing.

If you notice these less serious side effects, talk with your doctor:

• Headache or throat irritation.

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088