When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use if you had an allergic reaction to brimonidine.

How to Use This Medicine:
Gel/Jelly

• This medicine is for use on the face only. Do not use this medicine in your eyes, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.
• Wash your hands with soap and water before and after you use this medicine.
• Apply a amount about the size of a pea to each of the 5 areas of the face: central forehead, chin, nose, and each cheek. Rub it in gently.
• Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
• Missed dose:Apply a dose as soon as you can. If it is almost time for your next dose, wait until then and apply a regular dose. Do not apply extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some foods and medicines can affect how brimonidine works. Tell your doctor if you are using any of the following:
  
  • Blood pressure medicine
  • Beta-blocker
  • Digoxin or similar heart medicine
  • MAO inhibitor

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have liver disease, circulation problems, depression, heart or blood vessel problems, low blood pressure, Raynaud phenomenon, scleroderma, Sjögren syndrome, or a history of stroke.
• This medicine may cause the following problems:
  
  • Serious side effects when swallowed (especially by a child)
• Do not use this medicine to treat a skin problem your doctor has not examined.
• Call your doctor if your symptoms do not improve or if they get worse.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing

If you notice these less serious side effects, talk with your doctor:

• Burning feeling, irritated skin, increased redness
• Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088