When This Medicine Should Not Be Used:
This medicine is not right for everyone. Tell your doctor if you had an allergic reaction to idursulfase, because you might need other medicine or a different schedule to prevent a reaction.

How to Use This Medicine:
Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, lung disease, or breathing problems.
• This medicine may cause a serious allergic reaction up to 24 hours after you receive it.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fast, pounding, or uneven heartbeat

If you notice these less serious side effects, talk with your doctor:

• Cough
• Diarrhea
• Mild skin itching
• Muscle or joint pain

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088