When This Medicine Should Not Be Used:
This medicine is not right for everyone. You should not receive it if you had an allergic reaction to ciprofloxacin or to similar medicines.

How to Use This Medicine:
Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein.
• A nurse or other health provider will give you this medicine.
• Drink extra fluids so you will urinate more often and help prevent kidney problems.
• This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.
• Your doctor may give you a few doses of this medicine until your condition improves. Then you may be switched to an oral medicine that works the same way. Talk to your doctor if you have concerns about this.

Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Do not use this medicine together with tizanidine.
• Some foods and medicines can affect how ciprofloxacin works. Tell your doctor if you are using any of the following:
  
  • Clozapine, cyclosporine, duloxetine, lidocaine, methotrexate, olanzapine, phenytoin, probenecid, ropinirole, sildenafil, or theophylline
  • Antibiotics (including azithromycin, clarithromycin, erythromycin)
  • Blood thinner (including warfarin)
  • Diabetes medicine
  • Heart rhythm medicine (including amiodarone, procainamide, quinidine, sotalol)
  • Medicine to treat depression or mental illness
  • NSAID pain or arthritis medicine (including aspirin, celecoxib, diclofenac, ibuprofen, naproxen)
  • Steroid medicine (including hydrocortisone, methylprednisolone, prednisone)
• This medicine slows the digestion of caffeine, so it might affect you for longer than normal.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, diabetes, myasthenia gravis, or a history of heart rhythm problems (including QT prolongation) or seizures. Tell your doctor if you have ever had tendon or joint problems, including rheumatoid arthritis, or if you have received a transplant.
• This medicine may cause the following problems:
  
  • Tendinitis and tendon rupture (may happen after treatment ends)
  • Nerve damage in the arms or legs
  • Liver damage
  • Heart rhythm changes
  • Changes in blood sugar levels
• This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything that could be dangerous until you know how this medicine affects you.
• This medicine can cause diarrhea. Call your doctor if the diarrhea becomes severe, does not stop, or is bloody. Do not take any medicine to stop diarrhea until you have talked to your doctor. Diarrhea can occur 2 months or more after you stop taking this medicine.
• This medicine may make your skin more sensitive to sunlight. Wear sunscreen. Do not use sunlamps or tanning beds.
• Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Blistering, peeling, red skin rash
• Change in how much or how often you urinate
• Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
• Diarrhea that may contain blood
• Fainting, dizziness, or lightheadedness
• Fast, slow, or uneven heartbeat
• Numbness, tingling, weakness, or burning pain in your hands, arms, legs, or feet
• Pain, stiffness, swelling, or bruises around your ankle, leg, shoulder, or other joint
• Seizures, severe headache, unusual thoughts or behavior, trouble sleeping, feeling anxious, confused, or depressed, seeing, hearing, or feeling things that are not there
• Unusual bleeding, bruising, or weakness

If you notice these less serious side effects, talk with your doctor:

• Pain, swelling, or redness where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088